ANESA blood count analyzer

The ANESA non-invasive blood picture analyzer allows us to perform a comprehensive examination of the body’s condition in 180-720 seconds. The device reads 131 biochemical, hemodynamic and immunological values of the organism. The ANESA non-invasive blood picture analyzer cannot be compared with any other device in the world. It is certified in the EU, Ukraine, Russia, China, Kazakhstan, Dubai, … The examination is done with five microprocessors, which are distributed throughout the body.

The ANESA analyzer is a portable, compact and non-invasive biochemical laboratory. The ANESA analyzer weighs only 250 grams and is quite small. It works on all modern Windows computers.

With the help of the device, it is possible to carry out an extremely fast preventive examination for a large number of people, and the procedure is not expensive. Based on the results, the therapist can perform a complex and extremely fast analysis of the organism, and all results are stored in the database and are available at any time for further statistical processing. Measurement and data processing are carried out according to the methods of dr. Malayhina.

Each therapist can attend a special introductory course where they learn how to work with the device.

Based on the calculation, all 131 defined values and his experience, the therapist determines the condition of the body and, if necessary, can also decide on additional diagnostics using standard, already established methods.

file-pdfAn example of ANESA analyzer analysis

The basic principle of operation of the ANESA analyzer

The operation of the ANESA analyzer is based on the flow of blood in the body and on the effects of the chemical reactions of nitrogen, oxygen, hydrogen and carbon on the flow. Temperature changes determine how active chemical elements are due to the influence of nitrogen compounds, hydrogen bonding, and changes in the oxygen solubility coefficient.

The purpose of the examination is to determine changes in the composition of blood elements and the state at the end of chemical reactions that regulate the consumption of oxygen and the emission of carbon dioxide in the body, which affects the concentration of proteins and lipids in the cell membrane. Considering that the ANESA analyzer measures the temperature with the help of optical sensors, the examination is completely harmless.

Operation of the ANESA analyzer

ANESA non-invasive analyzer of blood count and metabolites works on the basis of temperature measurement at biologically active “reference” points in the human body. At these points, the data is then uploaded to the computer via the keyboard, where the device processes it.

The analyzer has five sensors that are placed on the so-called biologically active points on the body.

The following bioactive or reference points:

  • bifurcation of the right and left carotid arteries (two points),
  • right and left armpit (two points),
  • navel area (one point).

Before starting the procedure, all five sensors are placed on the body, and the therapist enters personal data, breathing frequency and heart rate via the keyboard. The data collection and calculation program then performs its task. The analyzer processes the signals sent by sensors placed on the body, converts them into digital form and transmits them to the computer.

Operation of the ANESA device with the USPIH program

The ANESA device works according to a method based on the mutual connection between heat production and work produced in the blood flow system. The body produces heat as a result of chemical reactions of nitrogen, oxygen, hydrogen and carbon, as well as non-nitrogen compounds. Changes in temperature trigger the action of chemical elements, primarily oxygen. As a result of this action, the interdependence of nitrogen compounds, hydrogen compounds and the solubility coefficient of oxygen changes. All this affects changes in the oxygen solubility coefficient and the amount of carbon dioxide produced. Since these processes are self-regulating, they also change the protein and lipid content of the cell membrane.

The level of platelet phospholipid factor depends on proteins and lipids. Almost all blood cells have this factor. The course of the aforementioned chemical changes is genetically conditioned by hematopoiesis or blood formation (primitive blood cell differentiation potential is in the 49023 range for primitive blood cell division). This process depends on the level of oxygen supply, platelet phospholipid factor activity, oxygen solubility coefficient, pH value and temperature.

The function of hemoglobin of red blood cells (erythrocytes) is important in these processes, which depends on the conversion of bonds in NH and COOH molecules. These consist of glycine and succinic acid (both contain globin). Reactions take place cyclically – it is a continuous transition from one aggregate state to another (gas-liquid-crystalline substance). The degree of crystallization depends on the activity of phospholipids, triglycerides and cholesterol. Their action affects changes in the oxygen solubility coefficient, which also affects the phospholipid factor of platelets. The ANESA device has five sensors that must be placed on bioactive fields on the body (2 sensors on the left and right bifurcation of the aorta, 2 sensors under the left and right armpit, and 1 sensor on the navel area, where the aorta, descending vein and lymphatic channel).

During the operation of the ANESA device, the body is not exposed to any harmful influences. The ANESA device reads the influence of external conditions on the body (influence of air pressure, solar heat, etc.), or the degree of this influence in relation to the generation and emission of heat (enthalpy and entropy of energy). These values are conditioned by the genetic record of cellular elements in the blood and by biochemical parameters related to the establishment of homeostasis.

This method was described in more detail by A. Malykhin in his monograph Thermoregulation of the organism and vegetovascular paroxysms.

The theoretical basis for the operation of the ANESA analyzer

The human body is an open three-dimensional system with biosensors that detects all changes in the environment with the help of receptors for light, chemical stimuli, pressure and smells. The body processes all the received data and transmits it to the main organs through the system of transmitters (mediators), where the function of transmitters is performed by acetylcholine, norepinephrine, serotonin, and dopamine. The latter decide how much of a certain substance will be transferred from one place in the body to another. The described process is called mass transfer. Scientists have developed a method based on the kinetic laws of mass transfer, the functioning of receptors and transmitters, and on the molecular kinetic exponential relationship between the degree of response and temperature on the one hand, and the conversion of temperature into radiation energy on the other. This method is based on the connection of the body with the environment, which takes place through the co-influence of the enzyme hormone system and blood formation processes. It is based on the starting point established by Galzinge and Mauzuli in 1979 on the relationship between physical parameters and molecules of mediators – here we are talking, for example, about dipolar moment, molar refraction, and about properties that either stimulate or inhibit the course of biochemical reactions.

We developed this starting point according to our method and theoretically estimated the dipole moment using the vector method, relying on the distance between the nuclei of the chemical elements, the relative molar mass of the substance, the wavelength of Xe86 and other structural data, especially the linear dimension of cardiac and somatic capillaries , the diameter of red blood cells, body temperature, air pressure, composition of gases in the air, mass transfer function, and specific transfer, which is related to the oxygen diffusion coefficient.

The principle of operation of the ANESA non-invasive analyzer is based on the processing of data provided by temperature indicators from reference points (the bifurcation of the carotid artery on the left and right sides, the left and right armpit and the abdominal area). The principle is also based on the relationship between different values of the oxygen diffusion coefficient, the pH of the environment, and the occurrence of paroxysmal conditions.

The activity of the indicators listed above reflects the processes associated with the conversion of chemical bonds of the following elements: carbon, nitrogen, oxygen and hydrogen. These elements are found in the gas composition of the air, and they are also important for the biochemical homeostasis of the organism.

All chemical reactions in the body are exothermic (they release heat) and therefore affect body temperature. Temperature is related to the specific conductance that is transmitted across the synapses and thus affects the function of the receptors.

Transmission of signals across synapses depends on the combination of amino acids that make up the receptors.

Glycine with a specific conductance of 27.5 has an inhibitory effect on the functioning of synapses, while serotonin with a specific conductance of 41.5 stimulates their functioning. Acetylcholine has both a stimulating and an inhibitory effect (specific conductance 52.5).

In fact, the action of receptors and mediators is a mandatory mode of expression of all paroxysmal vegetative syndromes. The appearance of these syndromes is influenced by the changes that occur in the synthesis of glucose and serotonin. Vegetative paroxysmal states are the result of changes in the action of glucagon and insulin, which depends on the conductivity of the mediator system, and the conductivity is affected by mass transfer. In general, adaptation disorders often manifest as an interaction of arginine and glutamic acid. The most important factors here are the concentration of compounds and temperature, as they indicate the regulatory role of glycogen and insulin and the functioning of non-specific integrative systems in the brain. These systems determine the heat capacity and conductivity of the blood, and they also have a decisive influence on the blood count, breathing frequency and heart rate – especially because they determine the change in the aggregate states of substances.

Changing the states of matter is connected to the blood circulation through the composition of the peripheral blood. Namely, the necessary specific conductivity changes in the peripheral blood, as the nitrogen metabolism changes there. This is reflected in changes in glycogen, fat and protein metabolism. Blood circulation in the stomach and intestines and on the axis between the hypothalamus and the pituitary gland is related to the action of the amino acids glutamate, arginine, aspartate and glycine. When there is an interaction between amino acids, they activate oxygen to synthesize lactic acid, etc., and this is related to temperature.

As shown by the comparative analysis of clinical, biochemical and instrumental methods of diagnosis, the ultimate goal of vegetative regulation of homeostasis is the systematic regulation of the functioning of internal organs and non-specific regulatory systems in the brain. This can be achieved by improving the transport of substances and the metabolism of gases in the blood and blood circulation, and by maintaining a precisely defined partial pressure of oxygen on the periphery of the capillaries (35-40 mm Hg, which coincides with 65-70% saturation of hemoglobin with oxygen at a normal pH value and CO2).

The partial pressure of oxygen on the periphery of each capillary occurs only at certain values of heat capacity and conductivity, which affect the conductivity and concentration of lactic acid. This kind of systematic regulation of the course of reactions helps us to regulate pressure, volume and temperature (PVT) and osmotic pressure. The latter is influenced by the difference in the concentration of substances soluble in liquids, which are separated by a semipermeable membrane with complexes of lipids and proteins. These affect the rate of oxygen transfer and CO2 excretion, as they change the conductivity of glycine, serotonin and dopamine, which regulate the pH value. The listed amino acids in the area of the stomach, intestines and kidneys are connected by blood circulation, and they are also affected by changes in the metabolism of sodium and potassium.

The degree to which the blood circulation is affected is related to the defect in the transfer and metabolism of gases in the red blood cells. It depends on the properties of iron depth and valence (determined by oxidation and reduction processes in the amino acid glycine), which is detected by temperature indicators at reference points.

Any deviations from the level of oxygen supply and СО2 formation are accompanied by changes in the biophysical and morphometric characteristics of the cardio-respiratory system, gastro-intestinal system, liver and kidneys, as well as changes in the functional state of regulatory, non-specific mechanisms of the nervous system. These deviations lead to changes in the temperature indicators at the reference points, to changes in the time required for their stabilization and to changes in the activity of the thrombin and plasmin system (TPS) due to the altered platelet activation factor.

Platelet activating factor is associated with the action of carnitine and palmitic acid, which determine energy metabolism in relation to oxygen supply. This factor is also related to physical changes in oxygen (changed coefficient of diffusion and solubility of oxygen), which affect the capacity and conductivity of heat, as well as the number of active ions on the surface of red blood cells.

The mechanism that takes care of the level of oxygen supply to the body depends on the action of growth hormone, heart rate, respiratory rate, volume of structural circulation, pulse volume, general resistance of peripheral vessels and arterial blood pressure. Each of these values, on the one hand, depends on the change of the aggregate state from a gas to a liquid and to a crystalline substance, on the other hand, the transitions of the aggregate state are determined by the volume distribution of the structural circulation in the blood circulation of the internal organs, whose direction and action are regulated by enzymes. There is a direct relationship between the volume of structural blood circulation, the pulse volume and the general resistance of the peripheral vessels, which is reflected in the temperature indicators of the reference points. The display of temperature on the indicators combines values for heat production and work. Changes in indicators first lead to changes in the volume of structural blood circulation and vital lung capacity. As a result, various chemical changes of substances in the gaseous state occur, which depend on the constants in three types of reactions:

  1. rate of charge transfer reaction;
  2. degree of atom transfer reaction;
  3. dissolution of dissociative recombination reactions.

All of the above reactions are related to the oxygen solubility coefficient and are only possible when the energy source is the emission of heat, which is ultimately detected by the sensors of the ANESA analyzer.

The end result of these reactions are various conversions of enzyme groups. Enzymes from the first group of subclass 1 catalyze the oxidation of hydroxy groups to carbonyl groups, enzymes from subclass 2 catalyze the oxidation of carbonyl groups to carboxyl groups, enzymes from subclass 3 catalyze the oxidation of the СН-СН group to the С=С group, enzymes from subclass 4 catalyze the oxidation of СН groups -NH2, which usually causes the formation of carbonyl groups and an ion, enzymes from subclass 5 catalyze the oxidation of CH-NH groups, enzymes from subclass 8 act on sulfur-containing donor groups, and enzymes from subclass 10 act on biphenyls and related donor groups.

The analysis of correlation dependences on the concentration of sugar, urea and creatinine showed that the quantitative indicators are related to the temporal characteristics of the cardiac cycle, which are influenced by temperature indicators. Temporal characteristics also show the essence of the retroactive effect of the metabolic activity of the organs on the functioning of the brain. All this is reflected in the time required for the stabilization of the temperature indicator in the area of the abdomen compared to the time required for the stabilization of the temperature indicator in the area of the neck artery. Temperature indicators with respect to stabilization time show changes in the rate of oxygen transfer, which depends on the oxygen solubility coefficient. Changes in temperature indicators cause changes in the oxygen solubility coefficient and in the composition of the cells of the peripheral blood circulation, as well as changes in the course of oxidation-reduction processes, which are accompanied by changes in the functioning of the thrombin and plasmin systems. It has become quite clear that the physical diffusion of oxygen is the main force that ensures the supply of oxygen to the blood of the arteries. As oxygen is transported from the blood in the capillaries to the cells and from the cytoplasm to the organelles, more complex oxygen transport mechanisms are also triggered. These condition the occurrence of certain paroxysmal disturbances in the homeostasis of the autonomic nervous system (VNS).

We determined the relationship between the course of oxidation of free radicals and antioxidant protection in relation to the process of converting the cohesive energy of carbon, nitrogen, oxygen and hydrogen. We determined the relationship between arterial pressure and metabolism, which determines a person’s insulin resistance. The latter conditions the emergence of disorders in the resistance to carbohydrates, affects the increase in the concentration of triglycerides in combination with the reduced concentration of cholesterol in high-density lipoproteins and the conversion of the chemical energy of anhydride bonds in adenosine triphosphoric acid (ATA) into electrical energy, which is released in intracellular and extracellular sodium and potassium metabolism. The intracellular metabolism of sodium and potassium is related to the force of contraction of the heart muscle and the muscles in the vessels of the internal organs, which determine the influence of the perfusion pressure on the basal pressure of the sphincter of Oddi.

In the participating patients, metabolic disorders were closely related to structural and functional disorders of the heart muscle, and they were also related to the functioning of the gastro-intestinal system and the value of the change in basal pressure. The increased concentration of simple lipids in the blood serum directly affected the indicators of end-diastolic volume, end-systolic volume and pulse volume. The ratio of direct correlation was undoubtedly higher in patients who showed a combination of substrate with bonds from cholesterol and extremely low density lipoproteins (r = +0.35; +0.41; +0.36). The results showed a negative relationship between the concentration of simple lipids in blood serum and ejection fraction (r = -0.55; -0.59), and an increasing relationship between simple cholesterol in blood serum and stroke volume (r = +0.43; +0.48).

Changes in temperature conditions cause changes in diffusion, the oxygen solubility coefficient and the pH of the environment, thus determining the speed of the associated enzymatically produced coenzymes that regulate the functioning of internal organs (cytochrome P 450, which is a hemoprotein and a flavoprotein at the same time). Coproteins are regulated by the sympathetic-adrenal system (SAS), the pituitary-adrenal system (HAS), the thrombin and plasmin system, and the immunological system (spleen, spleen, lymph nodes), which are connected to the biophysical parameters of the heart muscle via blood flow.

Thus, we can come to two conclusions:

  • Any change in the atmosphere leads to changes in the functioning of the thrombin and plasmin system, and it is also accompanied by certain (usually subclinical) disturbances in the regulation of the vegetative system in the brain.
  • The extent to which disorders of the autonomic nervous system will manifest themselves depends on the asymmetry of the indicators at the examined points, the functional state of the systems and structures involved in the limbic-reticular complex and the thrombin and plasmin system, which affects the synthesis of cholesterol, triglycerides and lipoproteins extremely low density.

These relationships are universal in nature and are manifested both in the case of stress, chemical and physical influences, and in the case of tumors, injuries, and lateralized epileptic syndromes. It should be emphasized that the RMS value of oxygen flow (normally 467 ml/s) plays a big role in the appearance of clinical syndromes, which decides whether the enthalpy of energy is sufficient to break the ratio between CO or NO. Changes in the RMS value of oxygen flow are conditioned by acetylcholine, adrenaline and noradrenaline, and they are also influenced by changes in the functioning of red blood cells and flavoproteins with metalloproteins (Cu2+, Zn2+, Fe2+). Metalloproteins influence the course of the reaction

Н2О2 + НО2 ↔ Н2О2 + О2

A change in the course of the reaction to the right affects the activity of glutathione peroxidase enzymes (normal value 10.46 ± 0.27 mM/l); glutathione reductase (normal value 4.21 ± 0.14 mM/l) and on the reduction of glutathione and platelets (1.94 ± 0.04 mM/l).

The role of carbonic anhydrase is to ensure a balanced reaction:


If the concentration of СО2 increases, the reaction shifts to the left. In this case, the fat molecules become dehydrated, squeeze together and do not allow water-soluble substances to pass through the membrane. Membrane polarization increases the productive effect of quantitative indicators of the sympathetic-adrenal system (SAS), the pituitary-adrenal system (HAS), and the thrombin and plasmin systems.

The activation of SAS, HAS and the thrombin and plasmin system is accompanied by changes in the activation energy of sodium and potassium molecules, which are related to the reaction rate r=Ead – Ear, where Ead is the activation energy of the direct reaction, and Ear is the activation energy of the reverse reaction. These values are quantitatively related to heat capacity and conductivity.

Sodium-potassium-adenosine triphosphatase regulates ion exchange across the membrane. It is activated by potassium ions from the outside of the membrane and sodium ions from the inside of the membrane. This enzyme also requires magnesium ions and is inhibited by calcium. In our opinion, the mechanism that regulates the action of sodium-potassium-adenosine triphosphatase is related to changes in the aggregate state of substances and to the process of formation of Н2СО3 salt solutions, during which sodium and potassium ions are captured. In any case, it would be logical to conclude that due to the reduced membrane permeability caused by Н2СО3 (carbonic acid), less calcium will pass from the cavities of the endoplasmic reticulum system (EPS) into the cytoplasm, where this substance will activate myosin adenosine triphosphatase and consequently stimulate ion exchange . It is known that muscle relaxation leads to the return of Са++ to the EPS cavities, and that this element dissolves more easily in the protoplasm. The return of Са++ can only be achieved in the presence of adenosine triphosphatase, which activates sodium-potassium-adenosine triphosphatase and ion pumps, thereby providing cellular repolarization following depolarization during stimulation. This is also confirmed by the time parameters of the QT interval, which can be understood from the data of the electrocardiogram and quantitative indicators of plasmin. The above reactions can be influenced by changing the concentration of Н2СО3 at the membrane level. The concentration of Н2СО3 depends on the level of cellular metabolism and is controlled by the primary respiratory centers of origin.

Research of important neurochemical mechanisms on a real-time scale became possible when processes began to be investigated with the help of hardware and software packages for non-invasive diagnostics of regulatory mechanisms of homeostasis. We found out the importance of disorders in the metabolism of lactates and pyruvates, the extremely interesting role of lactate, which caused a crisis of the autonomic nervous system in many people, we explained disorders in the metabolism of glutamate, the insufficient number of brain systems for dopamine, the importance of the insufficient amount of hidden calcium, the possible role of the metabolism of neuropeptides in connection with the response of temperature indicators at reference points, and the state of SAS, SAH and the thrombin and plasmin system.

The “SUPIH” program enables us to:

  • To evaluate the state of the organism from the point of view of functional, hemodynamic balance, water metabolism and gas homeostasis, which are related to fermentative and immunological corrections;
  • To define a predisposition to diseases of the central nervous system, cardiovascular system, internal and locomotor apparatus, blood flow, metabolism and other pathologies.

For the central nervous system, we can determine:

  • blood flow to the cerebrum – sufficient or insufficient;
  • condition of the arteries in the cerebrum – narrowed or dilated;
  • the state of the venules in the cerebrum – narrowed or dilated;
  • signs of irregular blood flow in the veins of the large brain;
  • condition of the third cerebral ventricle (size);
  • the size of the cerebroventricular indicators;
  • spinal fluid pressure;
  • based on the concentration of potassium, sodium, calcium and magnesium in the blood, we determine the conductivity of the nervous system and muscles;
  • tendency to spasms and weak muscles;

For the cardiovascular system, we can note:

  • coronary cardiosclerosis;
  • disturbed blood circulation in the myocardium;
  • decrease in the amount of exhausted blood of the heart muscle;
  • increase in the amount of exhausted heart muscle blood;
  • arrhythmia, temporary parameters of the cardiac cycle;
  • type of blood circulation: hyperkinetic, normokinetic, hypokinetic.

For the lungs, we can determine:

  • dynamic vital capacity of the lungs;
  • excess lung capacity;
  • chronic bronchitis and chronic tracheobronchitis with elements of asthma;
  • chronic, inflammatory pneumonia;
  • lung elasticity;
  • pulmonary blood circulation.

For the liver, we can determine:

  • hepatic blood flow;
  • hepatitis;
  • cirrhosis.

For the kidneys, we can determine:

  • filtration disorders;
  • resorption disorders;
  • chronic kidney inflammation (nephritis);
  • glumeronephritis;
  • pyelonephritis.

According to the signs of water metabolism, we can determine:

  • a type of disturbance in the metabolism of water electrolytes – a prerequisite for osteochondrosis;
  • various forms of dyskinesia (impaired ability to move);
  • post-cellular hypohydration;
  • cellular hyperhydration;
  • cellular hypohydration.

When determining enzyme activity and analyzing dynamic and hemodynamic balance, water electrolyte metabolism and gas homeostasis, the device enables us to:

  • To assess the compensatory capacity of the body.
  • To determine the possible tendency to the appearance of chronic diseases in organs and systems.
  • To choose a suitable form of physiotherapy or to provide information about therapy, or to advise appropriate therapy or some other procedure, taking into account the causes of the disease and its pathogenesis.


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